Ntụle nke ikpughe ọrụ na 4,4′-methylene-bis-(2-chloroaniline) “MOCA” site na usoro mmetụta ọhụrụ maka nleba anya nke ndu.

Usoro nyocha nke akwụkwọ akụkọ, nke e ji nkọwa dị elu na nghọta siri ike, emepụtala nke ọma maka mkpebi nke 4,4'-methylene-bis-(2-chloroaniline), nke a na-akpọkarị "MOCA," na mmamịrị mmadụ. Ọ dị mkpa iburu n'obi na MOCA bụ carcinogen edekọtara nke ọma, yana ihe akaebe toxicological guzosiri ike na-akwado carcinogenicity ya na anụmanụ ụlọ nyocha dị ka oke, oke, na nkịta.

Tupu itinye usoro a emepụtara ọhụrụ na ntọala ọrụ nke ụwa, ndị otu nyocha ahụ buru ụzọ mee ihe ọmụmụ mbido obere oge site na iji oke. Ebumnuche bụ isi nke ọmụmụ ihe ọmụmụ a bụ iji chọpụta ma dokwuo anya ụfọdụ isi ihe dị iche iche metụtara mmịpụta urinary nke MOCA na ụdị anụmanụ-gụnyere akụkụ dị ka ọnụ ọgụgụ nke excretion, ụzọ metabolic, na windo oge maka ọkwa a na-achọpụta - ịtọ ntọala sayensị siri ike maka ntinye usoro nke usoro ahụ n'ụdị mmadụ.

Na-esochi mmecha na nkwado nke ọmụmụ ihe izizi, a na-eji usoro nchọpụta mmamịrị a arụ ọrụ iji chọpụta oke ikpughe ọrụ na MOCA n'etiti ndị ọrụ na ụlọ ọrụ mmepụta ihe French. Ogologo nke nyocha ahụ kpuchiri isi ihe abụọ dị iche iche nke ọrụ ọrụ jikọtara ya na MOCA: otu bụ usoro mmepụta mmepụta ihe nke MOCA n'onwe ya, nke ọzọ bụ iji MOCA dị ka onye na-agwọ ọrịa n'ichepụta polyurethane elastomers, ihe omume ngwa ngwa na-emekarị na ụlọ ọrụ kemịkalụ na ihe.

Site n'ule ule dị ukwuu nke ihe nlele mmamịrị anakọtara site n'aka ndị ọrụ na ọnọdụ ndị a, otu nyocha ahụ chọpụtara na ọkwa urinary excretion nke MOCA gosipụtara ụdị dịgasị iche iche. Kpọmkwem, mkpokọta mkpochapụ ahụ sitere na ọkwa anaghị achọpụta—akọwara dị ka ihe na-erughị 0.5 microgram kwa lita—ruo ihe karịrị 1,600 micrograms kwa lita. Na mgbakwunye, mgbe N-acetyl metabolites nke MOCA nọ na nlele mmamịrị, mkpokọta ha na-agbadata mgbe niile na nke dị ala karịa mkpokọta nne na nna (MOCA) n'otu ihe atụ ahụ, na-egosi na MOCA n'onwe ya bụ ụdị izizi a na-apụ na mmamịrị yana ihe ngosi a pụrụ ịdabere na ya nke ikpughe.

N'ozuzu, nsonaazụ a nwetara site na ntule mkpughe ọrụ a dị ukwuu pụtara n'ụzọ ziri ezi na n'ụzọ ziri ezi na-egosipụta ọkwa mgbasa ozi MOCA n'ozuzu nke ndị ọrụ nyochara, n'ihi na ọkwa nke excretion achọpụtara jikọtara ya na ọdịdị nke ọrụ ha, ogologo oge nke ikpughe, na ọnọdụ gburugburu ebe ọrụ. Ọzọkwa, otu nleba anya dị mkpa sitere na ọmụmụ ihe ahụ bụ na mgbe emechara mkpebi nyocha ahụ wee mejuputa usoro mgbochi ezubere iche n'ebe ọrụ - dị ka imeziwanye usoro ikuku ventilashị, ịkwalite ojiji nchekwa nke onwe (PPE), ma ọ bụ rụọ ọrụ usoro kachasị mma - ọkwa ọkwa urinary excretion nke MOCA na ndị ọrụ metụtara na-egosipụtakarị ngosipụta doro anya na mgbochi dị ịrịba ama, na-egosipụta arụmọrụ MOCA ndị a iji belata occupational occutional.