Glutaraldehyde Teknụzụ Frontier: Ọganihu na teknụzụ mgbochi Calcification

N'ihe gbasara akwara obi, glutaraldehyde ejiriwo ogologo oge na-agwọ anụ ahụ anụmanụ (dị ka bovine pericardium) maka mmepụta nke valves bioprosthetic. Otú ọ dị, otu aldehyde na-enweghị ihe fọdụrụ site na usoro omenala nwere ike iduga calcification mgbe etinyere ya, na-emebi ogologo oge nke ngwaahịa.

N'ịgbasa ihe ịma aka a, nchọpụta ọhụrụ e bipụtara na Eprel 2025 webatara usoro ọgwụgwọ mgbochi calcification ọhụrụ (aha ngwaahịa: Periborn), na-enweta ọganihu dị ịrịba ama.

1.Nkwalite teknụzụ isi:

Ngwọta a na-ewebata ọtụtụ mmezi isi na usoro njikọ njikọ glutaraldehyde ọdịnala:

Ngwakọta ihe mgbaze Organic:
A na-eme njikọ cross Glutaraldehyde na ihe mgbaze organic nke mejupụtara 75% ethanol + 5% octanol. Usoro a na-enyere aka wepu phospholipids anụ ahụ n'ụzọ dị irè n'oge njikọta-phospholipids bụ ebe izizi nucleation maka calcification.

Onye nnọchi anya na-ejuputa oghere:

Mgbe emechara njikọ, a na-eji polyethylene glycol (PEG) mee ihe dị ka ihe na-ejuputa oghere, na-abanye n'ime oghere dị n'etiti eriri collagen. Nke a abụọ na-echebe saịtị nucleation nke kristal hydroxyapatite ma gbochie infiltration nke calcium na phospholipids site na plasma nnabata.

Akara njedebe:

N'ikpeazụ, ọgwụgwọ na glycine na-ewepụ ihe fọdụrụnụ, otu aldehyde na-emeghachi omume, si otú ahụ wepụ isi ihe ọzọ na-akpalite calcification na cytotoxicity.

2. Ọpụrụiche ụlọ ọgwụ:

E tinyela nkà na ụzụ a n'ọkpụkpụ pericardial nke anụ ọhịa nke aha ya bụ "Periborn." Nnyocha nyocha nke ụlọ ọgwụ na-ekpuchi ndị ọrịa 352 karịrị afọ 9 gosipụtara nnwere onwe site n'ịrụ ọrụ n'ihi okwu metụtara ngwaahịa dị elu dị ka 95.4%, na-akwado ịdị irè nke atụmatụ mgbochi calcification ọhụrụ a na ogologo oge dị ogologo.

Mkpa ọ dị n'ọganihu a:

Ọ bụghị naanị na ọ na-edozi ihe ịma aka dị ogologo na ngalaba nke valves bioprosthetic, na-agbatị ogologo ndụ ngwaahịa, ma na-etinyekwa ume ọhụrụ n'ime ntinye nke glutaraldehyde n'ime ihe ndị dị elu nke biomedical.