Ọdịiche Teknụzụ Glutaraldehyde: Ihe ịga nke ọma na Teknụzụ Mgbochi Calcification

N'ihe gbasara ihe ndị e tinyere n'ime obi na akwara obi, a na-eji glutaraldehyde agwọ anụ ahụ anụmanụ (dịka ehi pericardium) maka mmepụta valvụ bioprosthetic. Agbanyeghị, otu aldehyde na-enweghị ihe fọdụrụ site na usoro ọdịnala nwere ike ibute calcification mgbe etinyere n'ime ahụ, na-emebi ogologo oge nke ngwaahịa ndị ahụ.

Iji dozie ihe ịma aka a, otu nnyocha ọhụrụ e bipụtara n'ọnwa Eprel afọ 2025 webatara ọgwụgwọ ọhụrụ maka igbochi kalsiyum (aha ngwaahịa: Periborn), nke na-enweta ọganihu dị ịrịba ama.

1. Mmelite Teknụzụ Isi:

Ngwọta a na-ewebata ọtụtụ mmezi dị mkpa na usoro njikọta glutaraldehyde ọdịnala:

Njikọta ihe mgbaze organic:
A na-eme njikọ Glutaraldehyde n'ime ihe mgbaze organic nke nwere 75% ethanol + 5% octanol. Ụzọ a na-enyere aka iwepụ phospholipids anụ ahụ nke ọma n'oge njikọta - phospholipids bụ ebe bụ isi maka njikọta nucleation.

Ihe Ndochi Oghere:

Mgbe ejikọtara ya na ibe ya, a na-eji polyethylene glycol (PEG) eme ihe dị ka ihe na-eme ka oghere dị n'etiti eriri collagen bata. Nke a na-echebe ebe nuklita nke kristal hydroxyapatite dị ma na-egbochi ịbanye na calcium na phospholipids site na plasma onye ọbịa.

Ihe mkpuchi njedebe:

N'ikpeazụ, ọgwụgwọ glycine na-eme ka otu aldehyde fọdụrụnụ, nke na-anaghị arụ ọrụ nke ọma, si otú a wepụ isi ihe ọzọ na-akpali calcification na cytotoxicity.

2. Nsonaazụ Ahụike Pụrụ Iche:

E jirila teknụzụ a mee ihe n'ebe a na-akpọ "Periborn" nke e ji agwọ ọrịa ehi. Nnyocha e mere n'ụlọọgwụ nke gbasara ndị ọrịa 352 karịrị afọ 9 gosiri na ha enweghị ike ịwa ahụ ọzọ n'ihi nsogbu ndị metụtara ngwaahịa dị elu ruo 95.4%, nke na-akwado irè nke atụmatụ ọhụrụ a na-egbochi kalsikaziya na ogologo oge ọ na-adịgide.

Ihe Mmalite A Pụtara:

Ọ bụghị naanị na ọ na-edozi nsogbu dị ogologo oge n'ọhịa nke valvụ bioprosthetic, na-agbatị ndụ ngwaahịa, kamakwa ọ na-etinye ike ọhụrụ n'ime ojiji nke glutaraldehyde na ihe ndị dị elu na biomedical.